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Details on Person LIG1 [nucleoplasm]

Class:IdEntityWithAccessionedSequence:53787
_displayNameLIG1 [nucleoplasm]
_timestamp2013-05-28 19:19:40
compartment[Compartment:7660] nucleoplasm
endCoordinate919
modified[InstanceEdit:109937] Gopinathrao, G, 2004-01-22 20:43:32
[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
[InstanceEdit:113515] Schmidt, EE, 2004-06-07 04:20:06
[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08
[InstanceEdit:2167809] D'Eustachio, P, 2012-03-20
[InstanceEdit:3132750] Wu, G, 2013-02-13
[InstanceEdit:3632907] Wu, G, 2013-05-28
nameLIG1
DNA ligase I
Polydeoxyribonucleotide synthase (ATP)
referenceEntity[ReferenceGeneProduct:53788] UniProt:P18858 LIG1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369012] R-HSA-53787.1
startCoordinate1
(activeUnit)[CatalystActivity:5651794] DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
[CatalystActivity:5651803] DNA ligase activity of LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm]
[CatalystActivity:9980014] DNA ligase activity of LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
(hasCandidate)[CandidateSet:9980180] XRCC4:LIG4, (LIG3:XRCC1, LIG1) [nucleoplasm] [Human herpesvirus 8]
(hasComponent)[Complex:110348] LIG1:APEX1 [nucleoplasm] [Homo sapiens]
[Complex:5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:5651790] LIG1:POLB:dsDNA [nucleoplasm] [Homo sapiens]
[Complex:5651808] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:5651810] LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] [Homo sapiens]
[Complex:9980008] LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
[Complex:9980179] LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-HHV8 dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
(hasMember)[DefinedSet:5690475] LIG1,LIG3:XRCC1 [nucleoplasm] [Homo sapiens]
(inferredFrom)[DefinedSet:1113349] Homologues of DNA ligase I [nucleoplasm] [Oryza sativa]
[EntityWithAccessionedSequence:1113980] B9G6D3 [nucleoplasm] [Oryza sativa]
(input)[Reaction:110371] LIG1 binds APEX1 and PCNA at SSB [Homo sapiens]
[Reaction:5651773] LIG1 binds POLB at long-patch BER site [Homo sapiens]
[BlackBoxEvent:9980021] LIG1 binds SSA sites [Homo sapiens]
(output)[Reaction:5651792] LIG1 and POLB dissociate from repaired dsDNA [Homo sapiens]
[Reaction:5651809] LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA [Homo sapiens]
[BlackBoxEvent:5686663] Completion of SSA [Homo sapiens]
[BlackBoxEvent:9858729] MITF-M-dependent LIG1 expression [Homo sapiens]
(physicalEntity)[CatalystActivity:109965] DNA ligase activity of LIG1 [nucleoplasm]
[CatalystActivity:5690630] DNA ligase activity of LIG1 [nucleoplasm]
(regulator)[Requirement:182796] Requirement by 'LIG1 [nucleoplasm]'
(updatedInstance)[_UpdateTracker:9871793] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v41:[modifyName]
[_UpdateTracker:9879951] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v44:[modifyEndCoordinate]
[_UpdateTracker:9886845] Update Tracker - [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] - v45:[addName]
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No pathways have been reviewed or authored by LIG1 [nucleoplasm] (53787)
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