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Details on Person UniProt:Q9NYJ7 DLL3
| Class:Id | ReferenceGeneProduct:53736 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-618 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NYJ7 DLL3 |
| _timestamp | 2024-11-03 19:40:39 |
| chain | signal peptide:1-26 chain:27-618 |
| checksum | 58A9BC0A7DEAD1A0 |
| comment | FUNCTION Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).SUBUNIT Can bind and activate Notch-1 or another Notch receptor.SUBCELLULAR LOCATION The DSL domain is required for binding to the Notch receptor.PTM Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Delta-like protein 3 alternativeName: Drosophila Delta homolog 3 shortName: Delta3 |
| geneName | DLL3 |
| identifier | Q9NYJ7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Differentiation Disease variant Disulfide bond Dwarfism EGF-like domain Membrane Notch signaling pathway Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DLL3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996526] ENSEMBL:ENSG00000090932 DLL3 [Homo sapiens] |
| secondaryIdentifier | DLL3_HUMAN E9PFG2 Q8NBS4 |
| sequenceLength | 618 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975082] UniProt:Q9NYJ7-1 DLL3 [Homo sapiens] [ReferenceIsoform:8975083] UniProt:Q9NYJ7-2 DLL3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1472881] DLL3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9793813] DLL3 [endosome membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NYJ7 DLL3 (53736)
