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Details on Person UniProt:Q8TDM6 DLG5
| Class:Id | ReferenceGeneProduct:53730 |
|---|---|
| _chainChangeLog | chain:1-1919 added on Fri February 6 2015 |
| _displayName | UniProt:Q8TDM6 DLG5 |
| _timestamp | 2024-11-03 19:45:27 |
| chain | chain:1-1919 |
| checksum | CC19273380260C92 |
| comment | FUNCTION Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).SUBUNIT Interacts with MPP1 (PubMed:9738934). Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (PubMed:12657639). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (PubMed:28169360). Interacts with CTNB1, SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (By similarity).INTERACTION Localized at sites of cell-cell contact.ALTERNATIVE PRODUCTS Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.DOMAIN The guanylate kinase-like domain interacts with the SH3 domain.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the MAGUK family. |
| description | recommendedName: Disks large homolog 5 alternativeName: Discs large protein P-dlg alternativeName: Placenta and prostate DLG |
| geneName | DLG5 KIAA0583 PDLG |
| identifier | Q8TDM6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Cytoskeleton Disease variant Membrane Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain Synapse |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DLG5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991815] ENSEMBL:ENSG00000151208 DLG5 [Homo sapiens] |
| secondaryIdentifier | DLG5_HUMAN A6H8Y3 Q149N1 Q5T1H7 Q5T1H8 Q6DKG3 Q86WC0 Q8TDM7 Q9UE73 Q9Y4E3 |
| sequenceLength | 1919 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:227187] UniProt:Q8TDM6-2 DLG5 [Homo sapiens] [ReferenceIsoform:227188] UniProt:Q8TDM6-3 DLG5 [Homo sapiens] [ReferenceIsoform:227189] UniProt:Q8TDM6-4 DLG5 [Homo sapiens] [ReferenceIsoform:227190] UniProt:Q8TDM6-5 DLG5 [Homo sapiens] [ReferenceIsoform:411889] UniProt:Q8TDM6-1 DLG5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9715164] DLG5 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8TDM6 DLG5 (53730)
