Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O14521 SDHD
| Class:Id | ReferenceGeneProduct:53642 |
|---|---|
| _chainChangeLog | transit peptide:1-56 added on Fri February 6 2015;chain:57-159 added on Fri February 6 2015 |
| _displayName | UniProt:O14521 SDHD |
| _timestamp | 2024-11-03 19:40:38 |
| chain | transit peptide:1-56 chain:57-159 |
| checksum | 6B1AA94831C8C3B6 |
| comment | FUNCTION Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10482792, PubMed:9533030). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle.SUBUNIT Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CybS family.ONLINE INFORMATION SDHD entry |
| description | recommendedName: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial shortName: CybS alternativeName: CII-4 alternativeName: Malate dehydrogenase [quinone] cytochrome b small subunit alternativeName: QPs3 alternativeName: Succinate dehydrogenase complex subunit D alternativeName: Succinate-ubiquinone oxidoreductase cytochrome b small subunit alternativeName: Succinate-ubiquinone reductase membrane anchor subunit |
| geneName | SDHD SDH4 |
| identifier | O14521 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Primary mitochondrial disease Proteomics identification Reference proteome Transit peptide Transmembrane Transmembrane helix Transport Tricarboxylic acid cycle |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SDHD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001715] ENSEMBL:ENSG00000204370 SDHD [Homo sapiens] |
| secondaryIdentifier | DHSD_HUMAN A6ND90 B3KQQ8 E9PIC0 E9PIG3 E9PQI9 Q53XW5 Q6IRW2 |
| sequenceLength | 159 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975962] UniProt:O14521-1 SDHD [Homo sapiens] [ReferenceIsoform:8975963] UniProt:O14521-2 SDHD [Homo sapiens] [ReferenceIsoform:8975964] UniProt:O14521-3 SDHD [Homo sapiens] [ReferenceIsoform:8975965] UniProt:O14521-4 SDHD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:70989] SDHD [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14521 SDHD (53642)
