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Details on Person Helleday, Thomas

Class:Id	Person:5362679
_displayName	Helleday, Thomas
_timestamp	2014-04-16 20:09:17
created	[InstanceEdit:5362685] D'Eustachio, Peter, 2014-04-16
firstname	Thomas
initial	T
surname	Helleday
(author)	[LiteratureReference:5362632] MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool [LiteratureReference:5362688] Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy [LiteratureReference:5651751] Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate [LiteratureReference:5685232] The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair [LiteratureReference:5686669] The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells [LiteratureReference:6785977] Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2 [LiteratureReference:9731602] MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP [LiteratureReference:9731608] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool [LiteratureReference:9750591] Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
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No pathways have been reviewed or authored by Helleday, Thomas (5362679)