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Details on Person CYP26A1,B1,C1 4-hydroxylate atRA

Class:Id	Reaction:5362525
_displayName	CYP26A1,B1,C1 4-hydroxylate atRA
_doRelease	TRUE
_timestamp	2014-11-20 02:44:07
authored	[InstanceEdit:5362519] Jassal, Bijay, 2014-04-16
catalystActivity	[CatalystActivity:5362526] retinoic acid 4-hydroxylase activity of CYP26A1,B1,C1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5362527] Jassal, Bijay, 2014-04-16
edited	[InstanceEdit:5362527] Jassal, Bijay, 2014-04-16
input	[Complex:5622116] SUMO-CRABP1:atRA [cytosol] [Homo sapiens] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5362575] Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid [LiteratureReference:215619] A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid [LiteratureReference:5365833] Cytochrome P450s in the regulation of cellular retinoic acid metabolism
modified	[InstanceEdit:5362573] Jassal, Bijay, 2014-04-16 [InstanceEdit:5365860] Jassal, Bijay, 2014-04-24 [InstanceEdit:5419222] Jassal, Bijay, 2014-05-01 [InstanceEdit:5419244] Jassal, Bijay, 2014-05-02 [InstanceEdit:5615664] Jassal, Bijay, 2014-07-28 [InstanceEdit:5615676] Jassal, Bijay, 2014-07-28 [InstanceEdit:5617025] Jassal, Bijay, 2014-07-30 [InstanceEdit:5621634] Jassal, Bijay, 2014-09-03 [InstanceEdit:5622087] Jassal, Bijay, 2014-09-10 [InstanceEdit:5622118] Jassal, Bijay, 2014-09-11 [InstanceEdit:5627269] Jassal, Bijay, 2014-10-17 [InstanceEdit:5633213] Matthews, Lisa, 2014-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP26A1,B1,C1 4-hydroxylate atRA
output	[SimpleEntity:5362521] 4OH-atRA [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [EntityWithAccessionedSequence:5334807] SUMO-K-CRABP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5622134] CRABP1 binds atRA [Homo sapiens] [Reaction:5362522] ALDHs oxidise atRAL to atRA [Homo sapiens]
releaseDate	2014-12-11
reviewed	[InstanceEdit:5615675] Duester, Gregg, 2014-07-28 [InstanceEdit:5621633] Napoli, Joseph, 2014-09-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644685] R-HSA-5362525.2
summation	[Summation:5362523] All-trans-retinoic acid (atRA) is a biologically activated ...
systematicName	CYP26A1,B1,C1 hydroxylate SUMO-CRABP1:atRA, NADPH, H+, O2 to SUMO-K-CRABP1, 4OH-atRA, NADP+, H2O
(hasEvent)	[Pathway:5365859] RA biosynthesis pathway [Homo sapiens]
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No pathways have been reviewed or authored by CYP26A1,B1,C1 4-hydroxylate atRA (5362525)