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Details on Person TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Class:Id	BlackBoxEvent:5362500
_displayName	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
_doRelease	TRUE
_timestamp	2017-07-26 05:50:56
authored	[InstanceEdit:5475178] Shamovsky, V, 2014-05-16
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:5362483] Shamovsky, V, 2014-04-16
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input	[Complex:5362479] TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5362506] Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
modified	[InstanceEdit:5362529] Shamovsky, V, 2014-04-16 [InstanceEdit:5483109] Shamovsky, V, 2014-05-16 [InstanceEdit:5492218] Shamovsky, V, 2014-05-20 [InstanceEdit:9013873] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
output	[Complex:5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644484] R-HSA-5362500.3
summation	[Summation:5362511] Upon stimulation by pathogen-associated inflammatory signals...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(precedingEvent)	[Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation [Homo sapiens] [Reaction:9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens] [Reaction:9823932] Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780641] Update Tracker - [BlackBoxEvent:5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - v62:[modifyText]
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No pathways have been reviewed or authored by TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (5362500)