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Details on Person Hh-Np binds GPC5

Class:Id	Reaction:5362427
_displayName	Hh-Np binds GPC5
_doRelease	TRUE
_timestamp	2014-11-20 02:56:07
authored	[InstanceEdit:5359176] Rothfels, Karen, 2014-04-08
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5362426] Rothfels, Karen, 2014-04-15
edited	[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
input	[CandidateSet:5362423] Hh-Np [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5362430] GPI-GPC5 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3247720] Hedgehog morphogen: from secretion to reception [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5362306] Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation [LiteratureReference:5362299] Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling [LiteratureReference:5362298] Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding [LiteratureReference:5362309] LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex [LiteratureReference:5362315] Role for amplification and expression of glypican-5 in rhabdomyosarcoma
modified	[InstanceEdit:5364683] Rothfels, Karen, 2014-04-21 [InstanceEdit:5483255] Rothfels, Karen, 2014-05-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh-Np binds GPC5
output	[Complex:5362428] Hh-Np:GPI-GPC5 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5362549] Hh-Np traffics to the plasma membrane [Homo sapiens] [Reaction:5358343] HHAT palmitoylates Hh N-terminal fragment [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645146] R-HSA-5362427.2
summation	[Summation:5362429] The establishment of a signaling gradient of Hh-Np is modula...
(hasEvent)	[Pathway:5362798] Release of Hh-Np from the secreting cell [Homo sapiens]
(precedingEvent)	[Reaction:5362553] NOTUM releases Hh-Np:GPC5 from the plasma membrane [Homo sapiens]
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No pathways have been reviewed or authored by Hh-Np binds GPC5 (5362427)