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Details on Person UniProt:P49448 GLUD2
Class:Id
ReferenceGeneProduct:53624
_chainChangeLog
transit peptide:1-53 added on Fri February 6 2015;chain:54-558 added on Fri February 6 2015
_displayName
UniProt:P49448 GLUD2
_timestamp
2025-02-21 19:58:14
chain
transit peptide:1-53 chain:54-558
checksum
F222B1B2CB74A6EA
comment
FUNCTION Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.CATALYTIC ACTIVITY L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)CATALYTIC ACTIVITY L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)SUBUNIT Homohexamer.INTERACTION Expressed in retina, testis and, at a lower level, brain.PTM Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.SIMILARITY Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
