Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q92506 HSD17B8
| Class:Id | ReferenceGeneProduct:53612 |
|---|---|
| _chainChangeLog | chain:1-261 added on Fri February 6 2015 |
| _displayName | UniProt:Q92506 HSD17B8 |
| _timestamp | 2026-02-20 21:38:54 |
| chain | chain:1-261 |
| checksum | 8B8B2D7131714D71 |
| comment | FUNCTION Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function (PubMed:19571038, PubMed:25203508, PubMed:30508570). Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) (PubMed:19571038). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) (PubMed:30508570). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol (PubMed:17978863).CATALYTIC ACTIVITY a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)CATALYTIC ACTIVITY 17beta-estradiol + NAD(+) = estrone + NADH + H(+)CATALYTIC ACTIVITY testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)CATALYTIC ACTIVITY 17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)PATHWAY Steroid biosynthesis; estrogen biosynthesis.PATHWAY Lipid metabolism; fatty acid biosynthesis.PATHWAY Lipid metabolism; mitochondrial fatty acid beta-oxidation.SUBUNIT Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.INTERACTION Widely expressed, particularly abundant in prostate, placenta and kidney (PubMed:17978863). Expressed at protein level in various tissues like brain, cerebellum, heart, lung, kidney, ovary, testis, adrenals and prostate (PubMed:30508570).INDUCTION Up-regulated by estradiol.MISCELLANEOUS The fatty acyl-CoA dehydrogenase activity is several thousand times higher than the estradiol and testosterone 17beta-hydroxysteroid dehydrogenase conversion.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| description | recommendedName: (3R)-3-hydroxyacyl-CoA dehydrogenase ecNumber evidence="7 8"1.1.1.n12 alternativeName: fullName evidence="11 13"17-beta-hydroxysteroid dehydrogenase 8 shortName: 17-beta-HSD 8 shortName evidence="13"HSD17B8 alternativeName: fullName evidence="13"3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit shortName evidence="13"KAR alpha subunit alternativeName: 3-oxoacyl-[acyl-carrier-protein] reductase alternativeName: Estradiol 17-beta-dehydrogenase 8 ecNumber evidence="5"1.1.1.62 alternativeName: Protein Ke6 shortName evidence="11 12"Ke6 alternativeName: Short chain dehydrogenase/reductase family 30C member 1 alternativeName: Testosterone 17-beta-dehydrogenase 8 ecNumber evidence="5"1.1.1.239 |
| geneName | HSD17B8 FABGL HKE6 RING2 SDR30C1 |
| identifier | Q92506 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Mitochondrion NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Steroid biosynthesis |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HSD17B8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962431] ENSEMBL:ENSG00000204228 HSD17B8 [Homo sapiens] |
| secondaryIdentifier | DHB8_HUMAN A6NLX7 Q5STP7 Q9UIQ1 |
| sequenceLength | 261 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8862105] HSD17B8 [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92506 HSD17B8 (53612)
