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Details on Person UniProt:P37058 HSD17B3
| Class:Id | ReferenceGeneProduct:53606 |
|---|---|
| _chainChangeLog | chain:1-310 added on Fri February 6 2015 |
| _displayName | UniProt:P37058 HSD17B3 |
| _timestamp | 2025-02-21 18:35:48 |
| chain | chain:1-310 |
| checksum | 0643FF35ED979185 |
| comment | FUNCTION Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:16216911, PubMed:26545797, PubMed:27927697, PubMed:8075637). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:26545797, PubMed:27927697). Testosterone is the key androgen driving male development and function (PubMed:8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:16216911, PubMed:26545797, PubMed:8075637). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911). Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697).CATALYTIC ACTIVITY a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + NADPH + H(+)CATALYTIC ACTIVITY testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH + H(+)CATALYTIC ACTIVITY 17beta-estradiol + NADP(+) = estrone + NADPH + H(+)CATALYTIC ACTIVITY 3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+)CATALYTIC ACTIVITY 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)CATALYTIC ACTIVITY androsterone + NADPH + H(+) = 5alpha-androstane-3alpha,17beta-diol + NADP(+)CATALYTIC ACTIVITY 3beta-hydroxy-5alpha-androstan-17-one + NADPH + H(+) = 5alpha-androstane-3beta,17beta-diol + NADP(+)CATALYTIC ACTIVITY androst-4-ene-3,11,17-trione + NADPH + H(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)CATALYTIC ACTIVITY 11beta-hydroxyandrost-4-ene-3,17-dione + NADPH + H(+) = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)PATHWAY Hormone biosynthesis; testosterone biosynthesis.PATHWAY Steroid metabolism.INTERACTION Testis.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
| description | recommendedName: 17-beta-hydroxysteroid dehydrogenase type 3 shortName evidence="12"17-beta-HSD 3 alternativeName: Estradiol 17-beta-dehydrogenase 2 ecNumber evidence="7"1.1.1.62 alternativeName: Short chain dehydrogenase/reductase family 12C member 2 alternativeName: Testicular 17-beta-hydroxysteroid dehydrogenase alternativeName: fullName evidence="14"Testosterone 17-beta-dehydrogenase 3 ecNumber evidence="4 5 6 7"1.1.1.64 |
| geneName | HSD17B3 EDH17B3 SDR12C2 |
| identifier | P37058 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disease variant Endoplasmic reticulum Lipid biosynthesis Lipid metabolism NADP Oxidoreductase Proteomics identification Pseudohermaphroditism Reference proteome Steroid biosynthesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | HSD17B3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995386] ENSEMBL:ENSG00000130948 HSD17B3 [Homo sapiens] |
| secondaryIdentifier | DHB3_HUMAN Q5U0Q6 |
| sequenceLength | 310 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973247] UniProt:P37058-1 HSD17B3 [Homo sapiens] [ReferenceIsoform:8973248] UniProt:P37058-2 HSD17B3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:192162] HSD17B3 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P37058 HSD17B3 (53606)
