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Details on Person UniProt:P14061 HSD17B1
| Class:Id | ReferenceGeneProduct:53602 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-328 added on Fri February 6 2015;initiator methionine:1 for 53602 removed on Fri Nov 03 2023;initiator methionine: for 53602 added on Fri Nov 03 2023;initiator methionine: for 53602 removed on Fri Aug 15 2025;initiator methionine:1 for 53602 added on Fri Aug 15 2025 |
| _displayName | UniProt:P14061 HSD17B1 |
| _timestamp | 2025-08-15 21:22:03 |
| chain | initiator methionine:1 chain:2-328 |
| checksum | 5B5C8909F9120832 |
| comment | FUNCTION Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH.CATALYTIC ACTIVITY 17beta-estradiol + NAD(+) = estrone + NADH + H(+)CATALYTIC ACTIVITY 17beta-estradiol + NADP(+) = estrone + NADPH + H(+)CATALYTIC ACTIVITY testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH + H(+)BIOPHYSICOCHEMICAL PROPERTIES Steroid biosynthesis; estrogen biosynthesis.SUBUNIT Homodimer. Exists predominantly as a homodimer but also exits as monomer.INTERACTION Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| description | recommendedName: fullName evidence="17"17-beta-hydroxysteroid dehydrogenase type 1 shortName: 17-beta-HSD 1 ecNumber evidence="1"1.1.1.51 alternativeName: 20 alpha-hydroxysteroid dehydrogenase shortName: 20-alpha-HSD alternativeName: E2DH alternativeName: fullName evidence="17"Estradiol 17-beta-dehydrogenase 1 ecNumber evidence="14"1.1.1.62 alternativeName: Placental 17-beta-hydroxysteroid dehydrogenase alternativeName: Short chain dehydrogenase/reductase family 28C member 1 |
| geneName | HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 SDR28C1 |
| identifier | P14061 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Direct protein sequencing Lipid biosynthesis Lipid metabolism NADP Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Steroid biosynthesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | HSD17B1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004651] ENSEMBL:ENSG00000108786 HSD17B1 [Homo sapiens] |
| secondaryIdentifier | DHB1_HUMAN B3KXS1 Q2M2L8 |
| sequenceLength | 328 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:804968] HSD17B1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4127421] HSD17B1 [photoreceptor outer segment membrane] [Homo sapiens] [EntityWithAccessionedSequence:4127422] HSD17B1 [photoreceptor outer segment membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P14061 HSD17B1 (53602)
