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Details on Person NNMT transfers CH3 from SAM to NAM to form MNA

Class:Id	Reaction:5359451
_displayName	NNMT transfers CH3 from SAM to NAM to form MNA
_doRelease	TRUE
_timestamp	2025-02-11 17:06:17
authored	[InstanceEdit:5359433] Jassal, B, 2014-04-11
catalystActivity	[CatalystActivity:159343] nicotinamide N-methyltransferase activity of NNMT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5359433] Jassal, B, 2014-04-11
crossReference	[DatabaseIdentifier:9938247] RHEA:23885
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
input	[SimpleEntity:197277] NAM [cytosol] [SimpleEntity:71284] AdoMet [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359447] Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization [LiteratureReference:5359445] Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization [LiteratureReference:5359458] Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity [LiteratureReference:5362158] 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
modified	[InstanceEdit:5362145] Jassal, B, 2014-04-15 [InstanceEdit:5362157] Jassal, B, 2014-04-15 [InstanceEdit:8855171] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:8940091] Jassal, Bijay, 2016-09-23 [InstanceEdit:8942223] Jassal, Bijay, 2016-10-11 [InstanceEdit:8943663] Jassal, Bijay, 2016-10-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938253] D'Eustachio, Peter, 2025-02-11
name	NNMT transfers CH3 from SAM to NAM to form MNA nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine
output	[SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:549282] MNA [cytosol]
releaseDate	2016-12-12
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8899690] R-HSA-5359451.3
summation	[Summation:5359454] Nicotinamide N-methyltransferase (NNMT) is a cytosolic prote...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939642] Update Tracker - [Reaction:5359451] NNMT transfers CH3 from SAM to NAM to form MNA - v92:[modifyText]
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