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Details on Person MSH2:MSH3 (MutSbeta) binds preferentially to insertions and ...
| Class:Id | Summation:5358921 |
|---|---|
| _displayName | MSH2:MSH3 (MutSbeta) binds preferentially to insertions and ... |
| _timestamp | 2014-05-23 10:11:20 |
| created | [InstanceEdit:5358925] May, Bruce, 2014-04-05 |
| modified | [InstanceEdit:5566523] May, Bruce, 2014-05-23 |
| text | MSH2:MSH3 (MutSbeta) binds preferentially to insertions and deletion loops (IDLs) of 2 bases or more (Palombo et al. 1996, Drummond et al. 1997, Genschel et al. 1998, Tian et al. 2009, Panigrahi et al. 2010, Kantelinen et al. 2010, Gupta et al. 2012). Unlike MSH2:MSH6 (MutSalpha), which binds the base of a mismatched nucleotide, MSH2:MSH3 binds 3 phosphates in the loop of unpaired nucleotides (Gupta et al. 2012). MSH2:MSH3 is localized at replication foci during S phase via an interaction between MSH3 and PCNA (Kleczkowska et al. 2001). |
| (summation) | [Reaction:5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more [Homo sapiens] |
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