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Details on Person EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

Class:Id	BlackBoxEvent:5358599
_displayName	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
_doRelease	TRUE
_timestamp	2016-03-18 15:00:25
authored	[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity	[CatalystActivity:5358637] 5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358539] May, Bruce, 2014-03-30
edited	[InstanceEdit:5358529] May, B, 2014-03-28
input	[Complex:5358633] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] [Homo sapiens] [Complex:68462] RPA heterotrimer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358627] Analysis of the excision step in human DNA mismatch repair [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358562] A defined human system that supports bidirectional mismatch-provoked excision [LiteratureReference:5358548] Mechanism of 5'-directed excision in human mismatch repair [LiteratureReference:5358587] The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair [LiteratureReference:5358575] Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction [LiteratureReference:5358563] Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A [LiteratureReference:5358683] Human exonuclease I is required for 5' and 3' mismatch repair [LiteratureReference:5358656] Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family [LiteratureReference:69372] Replication protein A (RPA): the eukaryotic SSB.
modified	[InstanceEdit:5358684] May, Bruce, 2014-03-30 [InstanceEdit:5358908] May, Bruce, 2014-04-05 [InstanceEdit:5358935] May, Bruce, 2014-04-05 [InstanceEdit:5364050] May, Bruce, 2014-04-18 [InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09 [InstanceEdit:5566517] May, Bruce, 2014-05-23 [InstanceEdit:5566523] May, Bruce, 2014-05-23 [InstanceEdit:5643863] Matthews, Lisa, 2014-11-18 [InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
output	[Complex:5358538] RPA:DNA containing single strand gap [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) [Homo sapiens] [Reaction:5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644757] R-HSA-5358599.3
summation	[Summation:5358547] EXO1 exonucleolytically degrades the strand being repaired i...
(hasEvent)	[Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) [Homo sapiens]
(inferredFrom)	[BlackBoxEvent:5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) [Homo sapiens]
(precedingEvent)	[Reaction:5358579] DNA polymerase delta polymerizes DNA across single stranded gap [Homo sapiens]
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No pathways have been reviewed or authored by EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (5358599)