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Details on Person DNA ligase I ligates single stranded nick in double stranded DNA

Class:Id	Reaction:5358592
_displayName	DNA ligase I ligates single stranded nick in double stranded DNA
_doRelease	TRUE
_timestamp	2015-04-29 18:27:06
authored	[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity	[CatalystActivity:5690630] DNA ligase activity of LIG1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358539] May, Bruce, 2014-03-30
edited	[InstanceEdit:5358529] May, B, 2014-03-28
input	[SimpleEntity:29358] ATP [nucleoplasm] [OtherEntity:5358610] DNA containing single strand nick (5' phosphate, 3' hydroxyl) [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358862] Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency [LiteratureReference:5358863] DNA ligases: structure, reaction mechanism, and function [LiteratureReference:5358900] Purification and properties of two DNA ligases from human placenta [LiteratureReference:5358885] Differential recruitment of DNA Ligase I and III to DNA repair sites [LiteratureReference:5358859] Mechanism underlying replication protein a stimulation of DNA ligase I
modified	[InstanceEdit:5358684] May, Bruce, 2014-03-30 [InstanceEdit:5358908] May, Bruce, 2014-04-05 [InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09 [InstanceEdit:5566517] May, Bruce, 2014-05-23 [InstanceEdit:5566523] May, Bruce, 2014-05-23 [InstanceEdit:5690631] Orlic-Milacic, Marija, 2015-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DNA ligase I ligates single stranded nick in double stranded DNA
output	[OtherEntity:109966] Repaired double-stranded DNA [nucleoplasm] [SimpleEntity:164121] AMP [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent	[Reaction:5358579] DNA polymerase delta polymerizes DNA across single stranded gap [Homo sapiens] [BlackBoxEvent:5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) [Homo sapiens] [BlackBoxEvent:5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644406] R-HSA-5358592.2
summation	[Summation:5358851] LIG1 (DNA ligase I) catalyzes the formation of a phosphodies...
(hasEvent)	[Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) [Homo sapiens] [Pathway:5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784769] Update Tracker - [Reaction:5358592] DNA ligase I ligates single stranded nick in double stranded DNA - v53:[add_removeCatalystActivity]
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No pathways have been reviewed or authored by DNA ligase I ligates single stranded nick in double stranded DNA (5358592)