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Details on Person DNA polymerase delta polymerizes DNA across single stranded gap

Class:Id	Reaction:5358579
_displayName	DNA polymerase delta polymerizes DNA across single stranded gap
_doRelease	TRUE
_timestamp	2014-11-20 02:54:43
authored	[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity	[CatalystActivity:69115] DNA-directed DNA polymerase activity of DNA Polymerase delta tetramer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358539] May, Bruce, 2014-03-30
edited	[InstanceEdit:5358529] May, B, 2014-03-28
input	[Complex:5358538] RPA:DNA containing single strand gap [nucleoplasm] [Homo sapiens] [SimpleEntity:29604] dATP [nucleoplasm] [SimpleEntity:30185] dCTP [nucleoplasm] [SimpleEntity:29892] dGTP [nucleoplasm] [SimpleEntity:30187] dTTP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358669] In vitro analysis of the zinc-finger motif in human replication protein A [LiteratureReference:5358651] DNA polymerase delta is required for human mismatch repair in vitro [LiteratureReference:5358647] DNA-repair reactions by purified HeLa DNA polymerases and exonucleases [LiteratureReference:5358950] DNA polymerase delta in DNA replication and genome maintenance
modified	[InstanceEdit:5358684] May, Bruce, 2014-03-30 [InstanceEdit:5358908] May, Bruce, 2014-04-05 [InstanceEdit:5358952] May, Bruce, 2014-04-06 [InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09 [InstanceEdit:5566517] May, Bruce, 2014-05-23 [InstanceEdit:5566523] May, Bruce, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DNA polymerase delta polymerizes DNA across single stranded gap
output	[Complex:68462] RPA heterotrimer [nucleoplasm] [Homo sapiens] [OtherEntity:5358610] DNA containing single strand nick (5' phosphate, 3' hydroxyl) [nucleoplasm]
precedingEvent	[BlackBoxEvent:5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) [Homo sapiens] [Reaction:5358545] EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) [Homo sapiens] [BlackBoxEvent:5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch [Homo sapiens] [Reaction:5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645098] R-HSA-5358579.2
summation	[Summation:5358906] DNA polymerase delta synthesizes DNA across a single-strande...
(hasEvent)	[Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) [Homo sapiens] [Pathway:5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) [Homo sapiens]
(precedingEvent)	[Reaction:5358592] DNA ligase I ligates single stranded nick in double stranded DNA [Homo sapiens]
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