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Details on Person MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

Class:Id	Reaction:5358513
_displayName	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more
_doRelease	TRUE
_timestamp	2014-11-20 02:39:52
authored	[InstanceEdit:5358529] May, B, 2014-03-28
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358520] May, Bruce, 2014-03-29
edited	[InstanceEdit:5358529] May, B, 2014-03-28
input	[Complex:5357508] MSH2:MSH3:ADP [nucleoplasm] [Homo sapiens] [OtherEntity:5358527] DNA containing IDL of 2 or more bases [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358638] hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci [LiteratureReference:5358608] DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair [LiteratureReference:5358620] Mechanism of mismatch recognition revealed by human MutS? bound to unpaired DNA loops [LiteratureReference:5358583] Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired [LiteratureReference:5358566] MutSbeta exceeds MutSalpha in dinucleotide loop repair [LiteratureReference:5358607] Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities [LiteratureReference:5358550] hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA [LiteratureReference:5357511] Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha
modified	[InstanceEdit:5358640] May, Bruce, 2014-03-30 [InstanceEdit:5358935] May, Bruce, 2014-04-05 [InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09 [InstanceEdit:5444528] Gillespie, Marc E, 2014-05-14 [InstanceEdit:5566517] May, Bruce, 2014-05-23 [InstanceEdit:5566523] May, Bruce, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more MutSbeta binds insertion/deletion loop of 2 bases or more
output	[Complex:5358532] MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5444511] Formation of MSH2:MSH3 Complex [Homo sapiens] [BlackBoxEvent:6806394] TP53 and AP-1 stimulate MSH2 expression [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644524] R-HSA-5358513.2
summation	[Summation:5358921] MSH2:MSH3 (MutSbeta) binds preferentially to insertions and ...
(hasEvent)	[Pathway:5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) [Homo sapiens]
(precedingEvent)	[Reaction:5358919] MSH2:MSH3 exchanges ADP for ATP [Homo sapiens]
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No pathways have been reviewed or authored by MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (5358513)