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Details on Person MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA

Class:Id	Reaction:5358510
_displayName	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA
_doRelease	TRUE
_timestamp	2025-11-15 03:45:21
authored	[InstanceEdit:5358529] May, B, 2014-03-28
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358520] May, Bruce, 2014-03-29
edited	[InstanceEdit:5358529] May, B, 2014-03-28
input	[Complex:5357522] MLH1:PMS2 [nucleoplasm] [Homo sapiens] [Complex:68440] PCNA homotrimer [nucleoplasm] [Homo sapiens] [Complex:5358934] MSH2:MSH6:ATP:DNA containing 1-2 base mismatch [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358590] hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA [LiteratureReference:5358632] DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes [LiteratureReference:5358638] hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358667] PCNA function in the activation and strand direction of MutL? endonuclease in mismatch repair [LiteratureReference:5358850] The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair [LiteratureReference:5358848] Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA) [LiteratureReference:5358903] Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes [LiteratureReference:5358882] Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates [LiteratureReference:5358917] MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta [LiteratureReference:5358581] ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
modified	[InstanceEdit:5358640] May, Bruce, 2014-03-30 [InstanceEdit:5358684] May, Bruce, 2014-03-30 [InstanceEdit:5358908] May, Bruce, 2014-04-05 [InstanceEdit:5358935] May, Bruce, 2014-04-05 [InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09 [InstanceEdit:5444528] Gillespie, Marc E, 2014-05-14 [InstanceEdit:5566517] May, Bruce, 2014-05-23 [InstanceEdit:5566523] May, Bruce, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9973671] May, Bruce, 2025-11-15
name	MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA MutSalpha binds ATP and recruits MutLalpha to mismatch
output	[Complex:5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5358912] MSH2:MSH6 exchanges ADP for ATP [Homo sapiens] [Reaction:5358525] MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop [Homo sapiens] [Reaction:5444523] Formation of MSH1:PMS2 Complex [Homo sapiens] [BlackBoxEvent:6806405] TP53 stimulates PMS2 expression [Homo sapiens] [BlackBoxEvent:6806392] TP53 stimulates MLH1 expression [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644180] R-HSA-5358510.3
summation	[Summation:5358880] After being activated by a mismatch, MSH2:MSH6 (MutSalpha) r...
(hasEvent)	[Pathway:5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) [Homo sapiens]
(inferredFrom)	[Reaction:5358519] MSH2:MSH3 recruits MLH1:PMS2 to mismatch and interacts with PCNA [Homo sapiens]
(precedingEvent)	[Reaction:5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984647] Update Tracker - [Reaction:5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - v96:[removeLiteratureReference]
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