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Details on Person DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2

Class:Id	Reaction:5358494
_displayName	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2
_doRelease	TRUE
_timestamp	2016-11-10 00:57:02
authored	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
catalystActivity	[CatalystActivity:5358378] 2-(3-amino-3-carboxypropyl)histidine synthase activity of DPH1:DPH2:DPH3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643943] 2-(3-amino-3-carboxypropyl)histidine synthase activity of DPH1:DPH2:DPH3 [cytosol] Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
edited	[InstanceEdit:5358471] D'Eustachio, Peter, 2014-03-28
input	[SimpleEntity:71284] AdoMet [cytosol] [EntityWithAccessionedSequence:5358472] nascent EEF2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358361] Insights into diphthamide, key diphtheria toxin effector [LiteratureReference:5358357] A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3 [LiteratureReference:5643724] Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis [LiteratureReference:5308144] Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2 [LiteratureReference:5358468] The biosynthesis and biological function of diphthamide [LiteratureReference:5358373] Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme
modified	[InstanceEdit:5643727] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:5643868] D'Eustachio, Peter, 2014-11-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2
output	[SimpleEntity:353106] MTAD [cytosol] [EntityWithAccessionedSequence:5358478] aminocarboxypropyl EEF2 [cytosol] [Homo sapiens]
regulatedBy	[PositiveRegulation:5358491] Positive regulation by 'DNAJC24 [cytosol]'
regulationReference	[RegulationReference:9642433] Positive regulation by 'DNAJC24 [cytosol]' Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2
releaseDate	2014-12-11
reviewed	[InstanceEdit:5643867] Liu, Shihui, 2014-11-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622918] R-HSA-5358494.5
summation	[Summation:5358497] The diphthamide biosynthesis protein 2 (DPH2) subunit of the...
(hasEvent)	[Pathway:5358493] Synthesis of diphthamide-EEF2 [Homo sapiens]
(precedingEvent)	[Reaction:5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 [Homo sapiens]
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