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Details on Person Autoproteolytic cleavage of Hh precursors

Class:Id	Reaction:5358340
_displayName	Autoproteolytic cleavage of Hh precursors
_doRelease	TRUE
_timestamp	2018-02-27 15:21:48
authored	[InstanceEdit:5357576] Rothfels, Karen, 2014-03-24
catalystActivity	[CatalystActivity:5364643] endopeptidase activity of NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:5358341] Rothfels, Karen, 2014-03-27
edited	[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
input	[SimpleEntity:174672] CHOL [endoplasmic reticulum lumen] [Complex:5490380] NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:208280] Cholesterol modification of hedgehog signaling proteins in animal development [LiteratureReference:5358225] Hedgehog signaling in development and cancer [LiteratureReference:5358231] Identification of a palmitic acid-modified form of human Sonic hedgehog [LiteratureReference:5358244] The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins [LiteratureReference:5358217] Functional characterization of sonic hedgehog mutations associated with holoprosencephaly [LiteratureReference:5358247] The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis [LiteratureReference:5358236] Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly [LiteratureReference:5358212] Cholesterol modification restricts the spread of Shh gradient in the limb bud [LiteratureReference:5358209] Autoproteolysis in hedgehog protein biogenesis [LiteratureReference:5358242] Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord [LiteratureReference:5358205] A conserved mechanism of Hedgehog gradient formation by lipid modifications [LiteratureReference:5358224] Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain [LiteratureReference:5358249] The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
modified	[InstanceEdit:5364661] Rothfels, Karen, 2014-04-21 [InstanceEdit:5364669] Rothfels, Karen, 2014-04-21 [InstanceEdit:5365815] Rothfels, Karen, 2014-04-21 [InstanceEdit:5483244] Rothfels, Karen, 2014-05-16 [InstanceEdit:5490382] Rothfels, Karen, 2014-05-20 [InstanceEdit:9035493] Rothfels, Karen, 2018-01-23 [InstanceEdit:9038466] Rothfels, Karen, 2018-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autoproteolytic cleavage of Hh precursors
output	[CandidateSet:5358332] N-terminal CHOL-Hh fragments [endoplasmic reticulum lumen] [Homo sapiens] [CandidateSet:5358286] C-terminal Hh fragments [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:174692] P4HB [endoplasmic reticulum lumen] [Homo sapiens]
precedingEvent	[Reaction:5358336] P4HB forms mixed disulphides with Hh precursors [Homo sapiens] [BlackBoxEvent:5362386] Glycosylation of Hh [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644197] R-HSA-5358340.3
summation	[Summation:5358284] Autoproteolytic processing of the Hh precursor is essential ...
(hasEvent)	[Pathway:5358346] Hedgehog ligand biogenesis [Homo sapiens]
(normalReaction)	[FailedReaction:5358460] HPE SHH variants don't undergo autoproteolytic cleavage [Homo sapiens] [BlackBoxEvent:5440854] SHH variants that don't undergo processing are shunted into the ERAD pathway [Homo sapiens]
(precedingEvent)	[Reaction:5358343] HHAT palmitoylates Hh N-terminal fragment [Homo sapiens] [Reaction:5362437] C-terminal Hh fragments are bound by lectins [Homo sapiens]
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No pathways have been reviewed or authored by Autoproteolytic cleavage of Hh precursors (5358340)