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Details on Person The mechanisms of Hedgehog signalling and its roles in development and disease

Class:IdLiteratureReference:5358245
_displayNameThe mechanisms of Hedgehog signalling and its roles in development and disease
_timestamp2014-03-27 20:34:03
author[Person:5358019] Briscoe, James
[Person:5358170] Thérond, Pascal P
created[InstanceEdit:5358246] Rothfels, Karen, 2014-03-27
journalNat. Rev. Mol. Cell Biol.
pages416-29
pubMedIdentifier23719536
titleThe mechanisms of Hedgehog signalling and its roles in development and disease
volume14
year2013
(literatureReference)[Pathway:5358346] Hedgehog ligand biogenesis [Homo sapiens]
[Pathway:5358351] Signaling by Hedgehog [Homo sapiens]
[Reaction:5362427] Hh-Np binds GPC5 [Homo sapiens]
[Reaction:5362437] C-terminal Hh fragments are bound by lectins [Homo sapiens]
[BlackBoxEvent:5362549] Hh-Np traffics to the plasma membrane [Homo sapiens]
[Pathway:5362798] Release of Hh-Np from the secreting cell [Homo sapiens]
[BlackBoxEvent:5610752] GLI3R translocates to the nucleus [Homo sapiens]
[BlackBoxEvent:5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal [Homo sapiens]
[Pathway:5610783] Degradation of GLI2 by the proteasome [Homo sapiens]
[Pathway:5610787] Hedgehog 'off' state [Homo sapiens]
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