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Details on Person TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC

Class:Id	Reaction:5357904
_displayName	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
_doRelease	TRUE
_timestamp	2022-08-10 21:59:50
authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input	[Complex:5357865] LUBAC [cytosol] [Homo sapiens] [Complex:5357756] TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5357863] Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
modified	[InstanceEdit:5626999] Shamovsky, V, 2014-10-14 [InstanceEdit:5627604] Shamovsky, V, 2014-10-20 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5643755] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5658081] Shamovsky, V, 2014-12-17 [InstanceEdit:5692568] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693172] Shamovsky, Veronica, 2015-05-14 [InstanceEdit:5693825] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:6792594] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9796634] Shamovsky, Veronica, 2022-08-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
output	[Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 [Homo sapiens] [Reaction:5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796637] R-HSA-5357904.3
summation	[Summation:5627000] Ubiquitinated TRAF2 and BIRC2/3 were reported to recruit an ...
systematicName	TNF-alpha:TNFR1:TRADD:RIPK1:TRAF2 binds LUBAC
(hasEvent)	[Pathway:5357956] TNFR1-induced NF-kappa-B signaling pathway [Homo sapiens]
(precedingEvent)	[Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG [Homo sapiens] [Reaction:5357822] LUBAC ubiquitinates RIP1 [Homo sapiens] [Reaction:5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Homo sapiens] [BlackBoxEvent:9793679] LUBAC ubiquitinates RIPK1 at K627 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9847022] Update Tracker - [Reaction:5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - v82:[modifyText]
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No pathways have been reviewed or authored by TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (5357904)