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Details on Person RIPK1 is cleaved by CASP8

Class:Id	BlackBoxEvent:5357828
_displayName	RIPK1 is cleaved by CASP8
_doRelease	TRUE
_timestamp	2020-08-30 11:55:59
authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
catalystActivity	[CatalystActivity:139951] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15 [InstanceEdit:9697673] Shamovsky, Veronica, 2020-08-19
input	[Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5357775] Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis [LiteratureReference:9687059] Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
modified	[InstanceEdit:5433147] Shamovsky, V, 2014-05-12 [InstanceEdit:5626949] Shamovsky, V, 2014-10-14 [InstanceEdit:5635908] Shamovsky, V, 2014-11-07 [InstanceEdit:5643755] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5692533] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693172] Shamovsky, Veronica, 2015-05-14 [InstanceEdit:5693814] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9686457] Shamovsky, Veronica, 2020-05-01 [InstanceEdit:9697735] Shamovsky, Veronica, 2020-08-20 [InstanceEdit:9698104] Shamovsky, Veronica, 2020-08-22 [InstanceEdit:9698853] Shamovsky, Veronica, 2020-08-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RIPK1 is cleaved by CASP8
output	[EntityWithAccessionedSequence:5212664] RIPK1(1-324) [cytosol] [Homo sapiens] [Complex:5357809] TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:139952] Caspase-8 processing in the DISC [Homo sapiens] [Reaction:141156] TRAIL-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:141159] TNF-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:73945] FAS-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:140978] TRADD:TRAF2:RIP1 binds FADD [Homo sapiens] [Reaction:83582] TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
requiredInputComponent	[Complex:2562550] active caspase-8 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25 [InstanceEdit:9697732] Lalaoui, Najoua, 2020-08-20 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797015] R-HSA-5357828.4
summation	[Summation:5433115] Receptor-interacting serine/threonine-protein kinase 1 (RIPK...
(hasEvent)	[Pathway:5357905] Regulation of TNFR1 signaling [Homo sapiens] [Pathway:5675482] Regulation of necroptotic cell death [Homo sapiens]
(normalReaction)	[FailedReaction:9693929] RIPK1 variant is not cleaved by CASP8 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776894] Update Tracker - [BlackBoxEvent:5357828] RIPK1 is cleaved by CASP8 - v74:[addLiteratureReference, add_removeInput, modifyText] [_UpdateTracker:9776940] Update Tracker - [BlackBoxEvent:5357828] RIPK1 is cleaved by CASP8 - v73:[modifyText]
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