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Details on Person TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG

Class:IdReaction:5357776
_displayNameTNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
_doReleaseTRUE
_timestamp2023-03-01 14:56:04
authored[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
edited[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input[Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
[Complex:5357749] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
modified[InstanceEdit:5626998] Shamovsky, V, 2014-10-14
[InstanceEdit:5627604] Shamovsky, V, 2014-10-20
[InstanceEdit:5632358] Jassal, Bijay, 2014-10-28
[InstanceEdit:5632370] Jassal, Bijay, 2014-10-28
[InstanceEdit:5634235] Shamovsky, V, 2014-11-03
[InstanceEdit:5643755] Shamovsky, Veronica, 2014-11-17
[InstanceEdit:5658148] Shamovsky, V, 2014-12-17
[InstanceEdit:5692561] Shamovsky, Veronica, 2015-05-12
[InstanceEdit:5693172] Shamovsky, Veronica, 2015-05-14
[InstanceEdit:5693822] Shamovsky, Veronica, 2015-05-18
[InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9816114] Shamovsky, Veronica, 2022-08-31
[InstanceEdit:9819127] Shamovsky, Veronica, 2022-11-01
[InstanceEdit:9820396] Shamovsky, Veronica, 2022-11-07
[InstanceEdit:9820616] Shamovsky, Veronica, 2022-11-14
[InstanceEdit:9829016] Shamovsky, Veronica, 2023-02-21
[InstanceEdit:9830261] Shamovsky, Veronica, 2023-03-01
nameTNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
output[Complex:5357936] TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:5357766] Negative regulation by 'RIPK1 deubiquitinases [cytosol]'
[NegativeRegulation:5634135] Negative regulation by 'RACK1 [cytosol]'
[PositiveRegulation:9819128] Positive regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane]'
[NegativeRegulation:9820386] Negative regulation by 'TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]'
regulationReference[RegulationReference:9642010] Negative regulation by 'GNB2L1 [cytosol]' RACK1 modulates NF-?B activation by interfering with the interaction between TRAF2 and the IKK complex
[RegulationReference:9820390] Negative regulation by 'TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane]' Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
[InstanceEdit:9818965] Tu, Hailin, 2022-10-31
[InstanceEdit:9828415] Munitić, Ivana, 2023-02-14
[InstanceEdit:9830259] Franjkić, Toni, 2023-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796633] R-HSA-5357776.5
summation[Summation:5357963] K63-polyubiquitinated RIPK1 binds to IKBKG (NEMO), resulting...
(hasEvent)[Pathway:5357956] TNFR1-induced NF-kappa-B signaling pathway [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783067] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v57:[modifyText]
[_UpdateTracker:9846768] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v84:[modifyText]
[_UpdateTracker:9846840] Update Tracker - [Reaction:5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - v83:[addRegulator, modifyText]
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No pathways have been reviewed or authored by TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (5357776)
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