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Details on Person BIRC(cIAP1/2) ubiquitinates RIPK1

Class:Id	BlackBoxEvent:5357757
_displayName	BIRC(cIAP1/2) ubiquitinates RIPK1
_doRelease	TRUE
_timestamp	2022-08-11 01:55:57
authored	[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
catalystActivity	[CatalystActivity:5357912] ubiquitin-protein transferase activity of TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
input	[Complex:5357866] TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation [LiteratureReference:5357874] Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
modified	[InstanceEdit:5626945] Shamovsky, V, 2014-10-14 [InstanceEdit:5633212] Matthews, Lisa, 2014-10-31 [InstanceEdit:5643755] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5692527] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5692559] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693171] Shamovsky, Veronica, 2015-05-14 [InstanceEdit:5693809] Shamovsky, Veronica, 2015-05-18 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9794240] Shamovsky, Veronica, 2022-06-30 [InstanceEdit:9796659] Shamovsky, Veronica, 2022-08-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BIRC(cIAP1/2) ubiquitinates RIPK1
output	[Complex:5357756] TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) [Homo sapiens] [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
requiredInputComponent	[Complex:1234116] UBE2D1,2,3:Ubiquitin [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796632] R-HSA-5357757.3
summation	[Summation:5357935] Receptor-interacting protein 1 (RIPK1) polyubiquitination is...
systematicName	TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 ubiquitinates TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 to form TNF-α:TNF-R1:TRADD:K63polyUb-RIPK1:BIRC2,3,4
(hasEvent)	[Pathway:5357956] TNFR1-induced NF-kappa-B signaling pathway [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5357845] K63polyUb-RIPK1 is deubiquitinated [Homo sapiens] [Reaction:5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Homo sapiens] [Reaction:5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC [Homo sapiens] [Reaction:5357928] CLIP3 and CYLD bind TNF signaling complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846821] Update Tracker - [BlackBoxEvent:5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - v83:[modifyText] [_UpdateTracker:9846948] Update Tracker - [BlackBoxEvent:5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - v82:[modifyText]
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