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Details on Person UniProt:O00273 DFFA

Class:Id	ReferenceGeneProduct:53564
_chainChangeLog	chain:1-331 added on Fri February 6 2015
_displayName	UniProt:O00273 DFFA
_timestamp	2024-11-03 19:45:24
chain	chain:1-331
checksum	8656FE45DB003DF3
comment	FUNCTION Inhibitor of the caspase-activated DNase (DFF40).SUBUNIT Heterodimer of DFFA and DFFB.INTERACTION Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
description	recommendedName: DNA fragmentation factor subunit alpha alternativeName: DNA fragmentation factor 45 kDa subunit shortName: DFF-45 alternativeName: Inhibitor of CAD shortName: ICAD
geneName	DFFA DFF1 DFF45 H13
identifier	O00273
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Apoptosis Cytoplasm Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	DFFA
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991807] ENSEMBL:ENSG00000160049 DFFA [Homo sapiens]
secondaryIdentifier	DFFA_HUMAN Q5T6G5 Q5T6G6 Q96I97 Q9Y6C6
sequenceLength	331
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:146310] UniProt:O00273-2 DFFA [Homo sapiens] [ReferenceIsoform:401101] UniProt:O00273-1 DFFA [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:211185] DFFA(1-117) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:211188] DFFA(225-331) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:211199] DFFA(118-331) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:211205] DFFA(118-224) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:211221] DFFA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:211228] DFFA(1-?) [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O00273 DFFA (53564)