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Details on Person UniProt:P15924 DSP
| Class:Id | ReferenceGeneProduct:53556 |
|---|---|
| _chainChangeLog | chain:1-2871 added on Fri February 6 2015 |
| _displayName | UniProt:P15924 DSP |
| _timestamp | 2026-02-20 21:38:52 |
| chain | chain:1-2871 |
| checksum | 5770CC6B4F9F9F7B |
| comment | FUNCTION A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25733715). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (By similarity). Not required for preimplantation morphogenic process in blastocysts (By similarity). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (By similarity). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (By similarity). Plays a key role in adhesion and organization of the dermal epithelial barrier (By similarity). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (By similarity). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (By similarity). Required for the normal formation of the heart, also required for development of vascular capillary structures and intact endothelial cell barriers (By similarity). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (By similarity). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (By similarity). Required for the survival and maintenance of germ cells in the gonads during embryonic development (By similarity). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (PubMed:31595153).SUBUNIT Homodimer. Identified in a complex containing at least DSP, JUP, VIM and CDH2; the complex is more abundant following crush injury in regenerating motor neurons and may promote axon outgrowth and motor fiber repair (By similarity). Interacts with COL17A1 (via cytoplasmic region) (PubMed:12482924). Interacts with DSC2 (PubMed:21062920). Interacts with PKP2 (PubMed:11790773, PubMed:22781308). Interacts with PKP1 (PubMed:10852826, PubMed:11790773, PubMed:23444369). Interacts weakly with TMEM65. Interacts with NIN: the interaction facilitates recruitment of NIN to desmosome cell-cell junctions (By similarity). Interacts with TRF2 in the nucleus; the interaction is required for DSP telomere binding (PubMed:31595153).INTERACTION Localizes to desmosome precursor particles in the cytoplasm (PubMed:25208567). Localizes to the cytoplasm in undifferentiated keratinocytes however becomes localizes to both lateral and tricellular cell-cell contacts as differentiation progresses and as epithelial sheet formation completes (By similarity). Localizes to the interface of the cortical keratin network and endodermal cell periphery in developing embryos (By similarity).ALTERNATIVE PRODUCTS Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). Expressed in the heart in the heart (at protein level) (PubMed:18662195).TISSUE SPECIFICITY Apparently an obligate constituent of all desmosomes.TISSUE SPECIFICITY Resides predominantly in tissues and cells of stratified origin.DOMAIN The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of PKP1.PTM Methylation by PRMT1 promotes GSK3B-mediated phosphorylation cascade of multiple serine residues at the C-terminus resulting in trafficking to desmosome cell-cell junctions.PTM Phosphorylation by GSK3B occurs sequentially from Ser-2849 along multiple serine residue at the C-terminus. Hyperphosphorylation by GSK3B results in recruitment to desmosome cell-cell junction and promotion of intercellular adhesion (PubMed:25733715). Phosphorylation at Ser-2849 increases association with intermediate filament cytokeratin, potentially facilitating interaction between desmosome junctions and intermediate filament architecture (PubMed:33596089).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Minor isoform.SIMILARITY Belongs to the plakin or cytolinker family.ONLINE INFORMATION Desmoplakin entry |
| description | recommendedName: fullName evidence="37"Desmoplakin shortName evidence="35"DP alternativeName: 250/210 kDa paraneoplastic pemphigus antigen |
| geneName | DSP |
| identifier | P15924 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cardiomyopathy Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Disease variant DNA-binding Epidermolysis bullosa Membrane Methylation Nucleus Palmoplantar keratoderma Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DSP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992403] ENSEMBL:ENSG00000096696 DSP [Homo sapiens] |
| secondaryIdentifier | DESP_HUMAN B2RTT2 D7RX09 O75993 Q14189 Q9UHN4 |
| sequenceLength | 2871 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:146308] UniProt:P15924-2 DSP [Homo sapiens] [ReferenceIsoform:403017] UniProt:P15924-1 DSP [Homo sapiens] [ReferenceIsoform:8965130] UniProt:P15924-3 DSP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201580] DSP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:351843] DSP(?-?) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6801396] DSP [ficolin-1-rich granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:8847736] DSP [cornified envelope] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P15924 DSP (53556)
