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Details on Person UniProt:O94760 DDAH1
| Class:Id | ReferenceGeneProduct:53496 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-285 added on Fri February 6 2015;initiator methionine:1 for 53496 removed on Fri Nov 03 2023;initiator methionine: for 53496 added on Fri Nov 03 2023;initiator methionine: for 53496 removed on Fri Aug 15 2025;initiator methionine:1 for 53496 added on Fri Aug 15 2025 |
| _displayName | UniProt:O94760 DDAH1 |
| _timestamp | 2025-08-15 21:37:12 |
| chain | initiator methionine:1 chain:2-285 |
| checksum | CD8875DF267EF39B |
| comment | FUNCTION Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.CATALYTIC ACTIVITY N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrullineCATALYTIC ACTIVITY N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamineACTIVITY REGULATION Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a covalent adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 8.5.SUBUNIT Monomer.ALTERNATIVE PRODUCTS Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.SIMILARITY Belongs to the DDAH family. |
| description | recommendedName: fullName evidence="10"N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 shortName: DDAH-1 shortName: Dimethylarginine dimethylaminohydrolase 1 ecNumber evidence="4 5 6 7"3.5.3.18 alternativeName: DDAHI alternativeName: Dimethylargininase-1 |
| geneName | DDAH1 DDAH |
| identifier | O94760 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Direct protein sequencing Hydrolase Metal-binding Proteomics identification Reference proteome S-nitrosylation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DDAH1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957972] ENSEMBL:ENSG00000153904 DDAH1 [Homo sapiens] |
| secondaryIdentifier | DDAH1_HUMAN Q5HYC8 Q86XK5 |
| sequenceLength | 285 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976957] UniProt:O94760-1 DDAH1 [Homo sapiens] [ReferenceIsoform:8976958] UniProt:O94760-2 DDAH1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6783970] DDAH1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8958304] DDAH1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O94760 DDAH1 (53496)
