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Details on Person UniProt:P11926 ODC1

Class:Id	ReferenceGeneProduct:53456
_chainChangeLog	chain:1-461 added on Fri February 6 2015
_displayName	UniProt:P11926 ODC1
_timestamp	2025-02-21 19:36:55
chain	chain:1-461
checksum	8CCB88CE80E823C5
comment	FUNCTION Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.CATALYTIC ACTIVITY L-ornithine + H(+) = putrescine + CO2COFACTOR Inhibited by S-nitrosylation (PubMed:10462479, PubMed:11461922). Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240). Inhibited by 1-amino-oxy-3-aminopropane (APA, an isosteric analog of putrescine) (PubMed:17407445). Irreversibly inhibited by alpha-difluoromethylornithine (DFMO) (PubMed:17407445).BIOPHYSICOCHEMICAL PROPERTIES kcat is 3.3 sec(-1) with L-ornithine as substrate.PATHWAY Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.SUBUNIT Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (Probable). Does not form a heterodimer with AZIN2 (By similarity).INTERACTION Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).PTM S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.DISEASE The disease is caused by variants affecting the gene represented in this entry. BABS is due to truncating variants that lead to a gain of function. This phenomenon apparently results from truncation proximal to or involving the C-terminal region of ODC1 protein, distal enough to allow escape from nonsense-mediated decay. A gain of function is corroborated by elevated plasma levels of N-acetylputrescine, with otherwise normal polyamine levels, in affected individuals.SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-II family.ONLINE INFORMATION Ornithine decarboxylase entry
description	recommendedName: Ornithine decarboxylase shortName: ODC ecNumber evidence="6"4.1.1.17
geneName	ODC1
identifier	P11926
isSequenceChanged	FALSE
keyword	3D-structure Decarboxylase Disease variant Hypotrichosis Lyase Phosphoprotein Polyamine biosynthesis Proteomics identification Pyridoxal phosphate Reference proteome S-nitrosylation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ODC1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991217] ENSEMBL:ENSG00000115758 ODC1 [Homo sapiens]
secondaryIdentifier	DCOR_HUMAN Q53TU3 Q6LDS9
sequenceLength	461
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:70689] PXLP-K69-ODC1 [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:517825] N6-pyridoxal phosphate-L-lysine at 69
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No pathways have been reviewed or authored by UniProt:P11926 ODC1 (53456)