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Details on Person UniProt:P27707 DCK
| Class:Id | ReferenceGeneProduct:53448 |
|---|---|
| _chainChangeLog | chain:1-260 added on Fri February 6 2015 |
| _displayName | UniProt:P27707 DCK |
| _timestamp | 2025-02-21 19:58:07 |
| chain | chain:1-260 |
| checksum | 626B9D2D6BED8DBC |
| comment | FUNCTION Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).CATALYTIC ACTIVITY 2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)CATALYTIC ACTIVITY 2'-deoxyadenosine + ATP = dAMP + ADP + H(+)CATALYTIC ACTIVITY 2'-deoxyguanosine + ATP = dGMP + ADP + H(+)BIOPHYSICOCHEMICAL PROPERTIES Homodimer.INTERACTION Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.SIMILARITY Belongs to the DCK/DGK family.CAUTION Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo. |
| description | recommendedName: Deoxycytidine kinase shortName: dCK ecNumber evidence="2 4 5 7 8 9"2.7.1.74 alternativeName: Deoxyadenosine kinase ecNumber evidence="4 5 7"2.7.1.76 alternativeName: Deoxyguanosine kinase ecNumber evidence="5 7"2.7.1.113 |
| geneName | DCK |
| identifier | P27707 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Direct protein sequencing Kinase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DCK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992988] ENSEMBL:ENSG00000156136 DCK [Homo sapiens] |
| secondaryIdentifier | DCK_HUMAN B2R8V6 Q5TZY7 Q6FI11 |
| sequenceLength | 260 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:73515] DCK [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P27707 DCK (53448)
