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Details on Person PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion

Class:Id	Reaction:5340560
_displayName	PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion
_doRelease	TRUE
_timestamp	2014-11-20 02:33:38
authored	[InstanceEdit:5340172] Rothfels, K, 2014-03-11
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5340559] Rothfels, K, 2014-03-19
disease	[Disease:1500689] cancer
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
input	[EntityWithAccessionedSequence:3238209] PORCN [endoplasmic reticulum membrane] [Homo sapiens] [ChemicalDrug:5340556] LGK974 [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:3238090] Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein [LiteratureReference:3238084] The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing [LiteratureReference:3238075] A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling [LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases [LiteratureReference:3238093] Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion [LiteratureReference:3238086] Structural basis of Wnt recognition by Frizzled [LiteratureReference:3247710] Porcupine-mediated lipidation is required for Wnt recognition by Wls [LiteratureReference:3247729] Lipid-independent secretion of a Drosophila Wnt protein [LiteratureReference:3238078] A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities [LiteratureReference:3247704] Precise regulation of porcupine activity is required for physiological Wnt signaling [LiteratureReference:5340554] Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
modified	[InstanceEdit:5358786] Rothfels, Karen, 2014-04-03 [InstanceEdit:5433127] Rothfels, Karen, 2014-05-12 [InstanceEdit:5545648] Rothfels, Karen, 2014-05-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion
output	[Complex:5340557] PORCN:LGK974 [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644306] R-HSA-5340560.2
summation	[Summation:5340558] Porcupine (PORCN) is an O-acyl-transferase that catalyzes th...
(hasEvent)	[Pathway:5340573] LGK974 inhibits PORCN [Homo sapiens]
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