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Details on Person GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol

Class:IdReaction:5339524
_displayNameGLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
_doReleaseTRUE
_timestamp2025-08-14 07:58:35
authored[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
catalystActivity[CatalystActivity:5358708] D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643945] D-glucose transmembrane transporter activity of GLUT1 / SLC2A1 tetramer [plasma membrane] Structural analysis of the GLUT1 facilitative glucose transporter (review).
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
edited[InstanceEdit:5339530] Jassal, Bijay, 2014-03-04
goBiologicalProcess[GO_BiologicalProcess:6808140] D-glucose transmembrane transport
input[SimpleEntity:70115] Glc [extracellular region]
literatureReference[LiteratureReference:70141] Structural analysis of the GLUT1 facilitative glucose transporter (review).
[LiteratureReference:8981572] FGF-21 as a novel metabolic regulator
[LiteratureReference:70159] The predicted ATP-binding domains in the hexose transporter GLUT1 critically affect transporter activity
modified[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:177968] D'Eustachio, P, 2006-04-12 15:22:45
[InstanceEdit:199720] D'Eustachio, P, 2007-07-11 20:28:53
[InstanceEdit:352529] D'Eustachio, P, 2008-06-03 19:24:11
[InstanceEdit:450085] D'Eustachio, P, 2009-12-11
[InstanceEdit:1442515] D'Eustachio, P, 2011-07-12
[InstanceEdit:5340612] Jassal, Bijay, 2014-03-20
[InstanceEdit:5358707] Jassal, B, 2014-04-01
[InstanceEdit:5674394] Jassal, Bijay, 2015-02-12
[InstanceEdit:8981528] D'Eustachio, Peter, 2017-03-09
[InstanceEdit:8981563] D'Eustachio, Peter, 2017-03-10
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9963472] Stephan, Ralf, 2025-08-14
nameGLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
negativePrecedingEvent[NegativePrecedingEvent:9963453] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region
[NegativePrecedingEvent:9963434] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
output[SimpleEntity:70113] Glc [cytosol]
precedingEvent
regulatedBy[PositiveRegulation:5340413] Positive regulation by 'FGF21 [extracellular region]'
[NegativeRegulation:5358720] Negative regulation by 'ATP [cytosol]'
releaseDate2015-03-19
reviewed[InstanceEdit:5674208] D'Eustachio, Peter, 2015-02-11
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679989] R-HSA-5339524.6
summation[Summation:5339532] Tetrameric GLUT1, the SLC2A1 gene product, associated with t...
(hasEvent)[Pathway:189200] Cellular hexose transport [Homo sapiens]
(normalReaction)[FailedReaction:5632804] SLC2A1 tetramer does not transport Glc from extracellular region to cytosol [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9963442] Futile Cycle: GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
[NegativePrecedingEvent:9963458] Futile Cycle: GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol
(updatedInstance)[_UpdateTracker:9781299] Update Tracker - [Reaction:5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - v61:[add_removeLiteratureReference, modifyText]
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