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| Class:Id | ReferenceGeneProduct:53379 |
|---|---|
| _chainChangeLog | chain:1-400 added on Fri February 6 2015 |
| _displayName | UniProt:P35462 DRD3 |
| _timestamp | 2026-02-20 21:58:26 |
| chain | chain:1-400 |
| checksum | 3E8426597D6C164D |
| comment | FUNCTION Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions (PubMed:39984436). Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior (PubMed:39984436). Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels (PubMed:10578130). Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders (PubMed:39984436). Promotes cell proliferation through MAP kinase signaling (PubMed:19520868). Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade (PubMed:31538542). Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity (By similarity).SUBUNIT Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884). Interacts with DRD1 (By similarity).SUBCELLULAR LOCATION Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.ALTERNATIVE PRODUCTS Brain.PTM Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).PTM Palmitoylated.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. Glycine at position 9 results in gain of function and is associated with susceptibility to essential tremor.DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry. Glycine at position 9 results in gain of function and may be a risk factor for schizophrenia.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: fullName evidence="22"D(3) dopamine receptor alternativeName: Dopamine D3 receptor |
| geneName | DRD3 |
| identifier | P35462 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Receptor Reference proteome Schizophrenia Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DRD3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988925] ENSEMBL:ENSG00000151577 DRD3 [Homo sapiens] |
| secondaryIdentifier | DRD3_HUMAN A1A4V5 Q4VBM8 |
| sequenceLength | 400 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:403823] UniProt:P35462-1 DRD3 [Homo sapiens] [ReferenceIsoform:8967378] UniProt:P35462-3 DRD3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:390834] DRD3 [plasma membrane] [Homo sapiens] |
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