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Details on Person UniProt:Q8N104 DEFB106A
Class:Id
ReferenceGeneProduct:53351
_chainChangeLog
signal peptide:1-20 added on Fri February 6 2015;peptide:21-65 added on Fri February 6 2015
_displayName
UniProt:Q8N104 DEFB106A
_timestamp
2023-11-03 18:23:25
chain
signal peptide:1-20 peptide:21-65
checksum
9D1C89BB0041E02D
comment
FUNCTION Has antibacterial activity (PubMed:12600824). Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:23938203).SUBUNIT Monomer (PubMed:23938203). Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203).SUBCELLULAR LOCATION Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).TISSUE SPECIFICITY Expressed specifically in epididymis and lung.SIMILARITY Belongs to the beta-defensin family.
