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Details on Person In the nucleus, cellular retinoic acid binding protein 2 (CR...
| Class:Id | Summation:5334790 |
|---|---|
| _displayName | In the nucleus, cellular retinoic acid binding protein 2 (CR... |
| _timestamp | 2014-09-11 13:15:58 |
| created | [InstanceEdit:5334843] Jassal, Bijay, 2014-02-27 |
| modified | [InstanceEdit:5615664] Jassal, Bijay, 2014-07-28 [InstanceEdit:5622118] Jassal, Bijay, 2014-09-11 |
| text | In the nucleus, cellular retinoic acid binding protein 2 (CRABP2), bound to all trans retinoic acid (atRA), directly binds to heterodimeric nuclear retinoic acid receptors (RAR:RXR) to form a complex through which atRA is channeled from the binding protein to RAR (Majumdar et al. 2011). The RAR:RXR heterodimer can be formed between any of three receptor isoforms for each; RARA, RARB, or RARG with RXRA, RXRB, or RXRG (Neiderreither and Dolle 2008). RARA requires sumoylation and phosphorylation for ligand binding and nuclear localisation (Zhu et al. 2009, Santos & Kim 2010). RAR:RXR bind to their RA response elements (RARE, composed of tandem direct repeats of 5'-AGGTCA-3' spaced by either 2 bp or 5 bp (DR2, DR5) in response to their physiological ligand atRA, and regulate gene expression in various biological processes. |
| (summation) | [Reaction:5334854] RAR:RXR binds SUMO-CRABP2:atRA [Homo sapiens] [Reaction:5634103] SUMO-CRABP2 dissociates from atRA:RAR:RXR [Homo sapiens] |
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No pathways have been reviewed or authored by In the nucleus, cellular retinoic acid binding protein 2 (CR... (5334790)
