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Details on Person HPV Suppressed FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8

Class:Id	Reaction:5334739
_displayName	HPV Suppressed FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
_doRelease	FALSE
_timestamp	2016-07-15 23:49:25
authored	[InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5334743] Gillespie, Marc E, 2014-02-26
disease	[Disease:5334690] papillomavirus infectious disease
figure	[Figure:141228] /figures/FasL_Fas_FADD_ProCaspase8.jpg
input	[Complex:43124] FASL:FAS Receptor Trimer:FADD [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:2672217] The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis
modified	[InstanceEdit:83604] Matthews, L, 2003-11-23 12:20:00 [InstanceEdit:83669] Matthews, L, 0000-00-00 00:00:00 [InstanceEdit:83683] Matthews, L, 2003-11-27 03:00:00 [InstanceEdit:83892] Matthews, L, 2003-12-10 03:30:00 [InstanceEdit:109912] Joshi-Tope, G, 2004-01-21 22:18:55 [InstanceEdit:109917] Joshi-Tope, G, 2004-01-22 15:11:19 [InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07 [InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15 [InstanceEdit:141243] Gillespie, ME, 2004-09-07 03:33:39 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2648974] D'Eustachio, P, 2012-11-21 [InstanceEdit:3597633] Shamovsky, V, 2013-05-22 [InstanceEdit:5334691] Gillespie, Marc E, 2014-02-24 [InstanceEdit:5338607] Gillespie, Marc E, 2014-03-03 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	HPV Suppressed FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
normalReaction	[Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens]
output	[Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:83650] FasL:Fas binds FADD [Homo sapiens] [Reaction:71050] Trimerization of the FASL:FAS receptor complex [Homo sapiens]
regulatedBy	[NegativeRegulation:2672194] Negative regulation by 'viral E6 [cytosol]'
regulationReference	[RegulationReference:9642497] Negative regulation by 'viral E6 [cytosol]' The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8894571] R-HSA-5334739.1
summation	[Summation:5334741] High risk strains of human papillomavirus (HPV), such as HPV...
(hasEvent)	[Pathway:5334688] Papillomavirus Host Interactions [Homo sapiens]
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No pathways have been reviewed or authored by HPV Suppressed FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (5334739)