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Details on Person DNMT3A:DNMT3L binds chromatin

Class:IdReaction:5334179
_displayNameDNMT3A:DNMT3L binds chromatin
_doReleaseTRUE
_timestamp2014-11-20 02:48:44
authored[InstanceEdit:5333792] May, B, 2014-02-21
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5334169] May, B, 2014-02-22
edited[InstanceEdit:5333792] May, B, 2014-02-21
inferredFrom
input[Complex:5334143] DNMT3A:DNMT3L [nucleoplasm] [Homo sapiens]
[Complex:3211736] Chromatin [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5334178] DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
[LiteratureReference:5334174] Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family
[LiteratureReference:5334162] Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation
[LiteratureReference:5334132] Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L
[LiteratureReference:5336390] Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
modified[InstanceEdit:5336405] May, B, 2014-03-02
[InstanceEdit:5615505] May, Bruce, 2014-07-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDNMT3A:DNMT3L binds chromatin
output[Complex:5334159] DNMT3A:DNMT3L:Chromatin [nucleoplasm] [Homo sapiens]
releaseDate2014-09-30
reviewed[InstanceEdit:5615504] Beekman, Renée, Martín-Subero, José I, 2014-07-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5622692] R-HSA-5334179.2
summation[Summation:5336249] DNMT3L is a non-catalytic homologue of DNMT3A and DNMT3B whi...
(hasEvent)[Pathway:5334118] DNA methylation [Homo sapiens]
(precedingEvent)[Reaction:5334152] DNMT3A:DNMT3L methylates cytosine in DNA [Homo sapiens]
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No pathways have been reviewed or authored by DNMT3A:DNMT3L binds chromatin (5334179)