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Details on Person DNMT3A:DNMT3L methylates cytosine in DNA

Class:Id	Reaction:5334152
_displayName	DNMT3A:DNMT3L methylates cytosine in DNA
_doRelease	TRUE
_timestamp	2014-11-20 02:37:45
authored	[InstanceEdit:5333792] May, B, 2014-02-21
catalystActivity	[CatalystActivity:5334175] DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of DNMT3A:DNMT3L:Chromatin [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5334169] May, B, 2014-02-22
edited	[InstanceEdit:5333792] May, B, 2014-02-21
inferredFrom	[Reaction:5336316] Dnmt3a:Dnmt3l methylates cytosine in DNA [Mus musculus]
input	[Complex:5334159] DNMT3A:DNMT3L:Chromatin [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5334174] Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family [LiteratureReference:5334132] Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L [LiteratureReference:5336377] DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo [LiteratureReference:5336270] The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L [LiteratureReference:5336333] Dynamic CpG island methylation landscape in oocytes and preimplantation embryos [LiteratureReference:5336388] Identification of preferential target sites for human DNA methyltransferases
modified	[InstanceEdit:5336405] May, B, 2014-03-02 [InstanceEdit:5615505] May, Bruce, 2014-07-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DNMT3A:DNMT3L methylates cytosine in DNA
output	[Complex:5334119] DNMT3A:DNMT3L:Chromatin with 5mC [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:5334179] DNMT3A:DNMT3L binds chromatin [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5615504] Beekman, Ren�e, Mart�n-Subero, Jos� I, 2014-07-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644442] R-HSA-5334152.2
summation	[Summation:5336366] DNMT3A methylates the 5 position of cytosine in DNA. As infe...
(hasEvent)	[Pathway:5334118] DNA methylation [Homo sapiens]
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No pathways have been reviewed or authored by DNMT3A:DNMT3L methylates cytosine in DNA (5334152)