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Details on Person DNMT1 methylates cytosine in hemimethylated DNA

Class:Id	Reaction:5334151
_displayName	DNMT1 methylates cytosine in hemimethylated DNA
_doRelease	TRUE
_timestamp	2014-11-20 02:50:15
authored	[InstanceEdit:5333792] May, B, 2014-02-21
catalystActivity	[CatalystActivity:5334139] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates of DNMT1:UHRF1:Chromatin with hemimethylC [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5334169] May, B, 2014-02-22
edited	[InstanceEdit:5333792] May, B, 2014-02-21
inferredFrom	[Reaction:5336369] Dnmt1 methylates cytosine in hemimethylated DNA [Mus musculus]
input	[Complex:5334113] DNMT1:UHRF1:Chromatin with hemimethylC [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5336315] The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism [LiteratureReference:212167] UHRF1 plays a role in maintaining DNA methylation in mammalian cells [LiteratureReference:565725] Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation [LiteratureReference:5336287] Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation [LiteratureReference:5340115] Cytosine methylation: remaining faithful
modified	[InstanceEdit:5336405] May, B, 2014-03-02 [InstanceEdit:5339616] May, B, 2014-03-07 [InstanceEdit:5339745] May, B, 2014-03-08 [InstanceEdit:5340117] May, B, 2014-03-09 [InstanceEdit:5615505] May, Bruce, 2014-07-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DNMT1 methylates cytosine in hemimethylated DNA
output	[Complex:5334142] DNMT1:UHRF1:Chromatin with symmetric methylC [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent	[Reaction:5334160] UHRF1:Chromatin binds DNMT1 [Homo sapiens] [Reaction:5334099] UHRF1 binds chromatin with hemimethylated cytosine [Homo sapiens]
releaseDate	2014-09-30
reviewed	[InstanceEdit:5615504] Beekman, Ren�e, Mart�n-Subero, Jos� I, 2014-07-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5622331] R-HSA-5334151.2
summation	[Summation:5339743] DNMT1 transfers a methyl group from S-adenosylmethionine to ...
(hasEvent)	[Pathway:5334118] DNA methylation [Homo sapiens]
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No pathways have been reviewed or authored by DNMT1 methylates cytosine in hemimethylated DNA (5334151)