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Details on Person TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes

Class:Id	Reaction:5334050
_displayName	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes
_doRelease	TRUE
_timestamp	2014-11-20 02:51:51
authored	[InstanceEdit:5333083] Rothfels, K, 2014-02-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5334049] Rothfels, K, 2014-02-21
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
input	[CandidateSet:5334046] TCF7L2/TCF7L1 [nucleoplasm] [Homo sapiens] [CandidateSet:5333992] CTBPs [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3361761] The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF [LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines [LiteratureReference:5334047] XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development [LiteratureReference:5334013] HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells [LiteratureReference:5334036] A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer [LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription
modified	[InstanceEdit:5358698] Rothfels, Karen, 2014-03-31 [InstanceEdit:5358795] Rothfels, Karen, 2014-04-03 [InstanceEdit:5422954] Rothfels, Karen, 2014-05-07 [InstanceEdit:5433095] Rothfels, Karen, 2014-05-12 [InstanceEdit:5545662] Rothfels, Karen, 2014-05-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes
output	[Complex:5334048] TCF7L2/TCF7L1:CTBPs [nucleoplasm] [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644991] R-HSA-5334050.2
summation	[Summation:5334015] In addition to repressing WNT-dependent targets through Grou...
(hasEvent)	[Pathway:4641265] Repression of WNT target genes [Homo sapiens]
(normalReaction)	[FailedReaction:5334052] TFC7L2 mutants don't bind CTBP [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes [Homo sapiens]
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No pathways have been reviewed or authored by TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (5334050)