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Details on Person CLCAs self cleave

Class:Id	Reaction:5333671
_displayName	CLCAs self cleave
_doRelease	TRUE
_timestamp	2014-11-20 02:35:28
authored	[InstanceEdit:5333641] Jassal, Bijay, 2014-02-20
catalystActivity	[CatalystActivity:5333721] metalloendopeptidase activity of CLCAs [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5333641] Jassal, Bijay, 2014-02-20
edited	[InstanceEdit:5333641] Jassal, Bijay, 2014-02-20
input	[DefinedSet:5333763] CLCAs [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5333726] hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels [LiteratureReference:5333662] Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents [LiteratureReference:5333677] Association of the hCLCA1 gene with childhood and adult asthma [LiteratureReference:5333664] Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway [LiteratureReference:5333646] A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma [LiteratureReference:5333751] Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation
modified	[InstanceEdit:5625190] Jassal, Bijay, 2014-10-03 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CLCAs self cleave
output	[DefinedSet:5333722] N-terminus CLCAs [plasma membrane] [Homo sapiens] [DefinedSet:5333737] C-terminus CLCAs [plasma membrane] [Homo sapiens]
regulatedBy	[PositiveRegulation:5336160] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2014-09-30
reviewed	[InstanceEdit:5625188] Hamann, Martine, 2014-10-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644374] R-HSA-5333671.3
summation	[Summation:5333667] Calcium-activated chloride channel regulators 1,2,3P and 4 (...
(hasEvent)	[Pathway:2672351] Stimuli-sensing channels [Homo sapiens]
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No pathways have been reviewed or authored by CLCAs self cleave (5333671)