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Details on Person GSSebGalNac is reduced and methylated to MeSebGalNac

Class:Id	BlackBoxEvent:5333608
_displayName	GSSebGalNac is reduced and methylated to MeSebGalNac
_doRelease	TRUE
_timestamp	2025-02-25 22:16:49
authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:9939363] methyltransferase activity of unknown selenosugar methylase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5333616] Williams, MG, 2014-02-19
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
inferredFrom	[BlackBoxEvent:5333614] GSSebGalNac is reduced and methylated to MeSebGalNac [Rattus norvegicus]
input	[SimpleEntity:71284] AdoMet [cytosol] [SimpleEntity:5357683] GSSebGalNac [cytosol]
internalReviewed	[InstanceEdit:9939372] D'Eustachio, Peter, 2025-02-25
isChimeric	FALSE
literatureReference	[LiteratureReference:5359360] Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range
modified	[InstanceEdit:5333618] Williams, MG, 2014-02-19 [InstanceEdit:5359122] Williams, MG, 2014-04-08 [InstanceEdit:5422928] Williams, MG, 2014-05-06 [InstanceEdit:5422935] Williams, MG, 2014-05-06 [InstanceEdit:6793107] D'Eustachio, Peter, 2015-08-30 [InstanceEdit:6793354] D'Eustachio, Peter, 2015-09-01 [InstanceEdit:6804163] D'Eustachio, Peter, 2015-10-08 [InstanceEdit:6804183] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9939357] D'Eustachio, Peter, 2025-02-25 [InstanceEdit:9939371] D'Eustachio, Peter, 2025-02-25 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	GSSebGalNac is reduced and methylated to MeSebGalNac
output	[SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:5357685] MeSebGalNac [cytosol]
precedingEvent	[BlackBoxEvent:5333607] GSSeH combines with bGalNAc derivative to form GSSebGalNac [Homo sapiens] [Reaction:2408542] GSSeSG is reduced to GSSeH and GSH by GSR [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812524] R-HSA-5333608.3
structureModified	[InstanceEdit:9939357] D'Eustachio, Peter, 2025-02-25
summation	[Summation:5422934] 1beta-glutathionylseleno-N-acetyl-D-galactosamine (GSSebGalN...
(hasEvent)	[Pathway:2408499] Formation of selenosugars for excretion [Homo sapiens]
(precedingEvent)	[Reaction:2408500] GSSeH condenses with GSH to form H2Se and GSSG [Homo sapiens] [Reaction:2408556] SeO3(2-) combines with GSH to form GSSeSG and GSSG [Homo sapiens] [BlackBoxEvent:5333609] MeSebGalNac is hydrolysed to MeSeH and bGalNac [Homo sapiens] [BlackBoxEvent:5333612] MeSebGalNac is oxidatively cleaved to MeSeO2H and 2-acetamidoglucal [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939814] Update Tracker - [BlackBoxEvent:5333608] GSSebGalNac is reduced and methylated to MeSebGalNac - v92:[removeCatalystActivity]
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