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Details on Person UniProt:Q13356 PPIL2
| Class:Id | ReferenceGeneProduct:53296 |
|---|---|
| _chainChangeLog | chain:1-520 added on Sat February 7 2015 |
| _displayName | UniProt:Q13356 PPIL2 |
| _timestamp | 2024-11-03 19:58:04 |
| chain | chain:1-520 |
| checksum | 3FFA51C3D82F0957 |
| comment | FUNCTION Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1 (PubMed:33509932). Interacts with isoform 2 of BSG (PubMed:15946952). Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.INTERACTION May also localize to the cytoplasm and the cell membrane.ALTERNATIVE PRODUCTS Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.SIMILARITY Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.CAUTION Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity due to the presence of a tyrosine instead of a tryptophan at position 389. |
| description | recommendedName: fullName evidence="13"RING-type E3 ubiquitin-protein ligase PPIL2 ecNumber evidence="4"2.3.2.27 alternativeName: fullName evidence="10"CYC4 alternativeName: fullName evidence="12"Cyclophilin-60 shortName evidence="12"Cyclophilin-like protein Cyp-60 shortName evidence="12"Cyp60 shortName evidence="12"hCyP-60 alternativeName: fullName evidence="14"Probable inactive peptidyl-prolyl cis-trans isomerase-like 2 shortName evidence="14"PPIase alternativeName: fullName evidence="13"Rotamase PPIL2 |
| geneName | PPIL2 |
| identifier | Q13356 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Spliceosome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PPIL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990330] ENSEMBL:ENSG00000100023 PPIL2 [Homo sapiens] |
| secondaryIdentifier | PPIL2_HUMAN Q13357 Q8TAH2 Q9BWR8 |
| sequenceLength | 520 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152401] UniProt:Q13356-2 PPIL2 [Homo sapiens] [ReferenceIsoform:405598] UniProt:Q13356-1 PPIL2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:204475] PPIL2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:9769562] PPIL2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13356 PPIL2 (53296)
