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Details on Person UniProt:P51841 GUCY2F
| Class:Id | ReferenceGeneProduct:53278 |
|---|---|
| _chainChangeLog | signal peptide:1-50 added on Sat February 7 2015;chain:51-1108 added on Sat February 7 2015 |
| _displayName | UniProt:P51841 GUCY2F |
| _timestamp | 2026-02-20 21:40:08 |
| chain | signal peptide:1-50 chain:51-1108 |
| checksum | B047BBF1A3C009F9 |
| comment | FUNCTION Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544). Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity).CATALYTIC ACTIVITY GTP = 3',5'-cyclic GMP + diphosphateACTIVITY REGULATION Activated by GUCA1B when free calcium ions concentration is low, and inhibited by GUCA1B when free calcium ions concentration is high (PubMed:15772651). Inhibited by RD3 (PubMed:29515371).SUBUNIT Homodimer (By similarity). Interacts with RD3; promotes the exit of GUCY2F from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (By similarity).SUBCELLULAR LOCATION Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.DOMAIN The protein kinase domain is predicted to be catalytically inactive.PTM There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.SIMILARITY Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| description | recommendedName: Retinal guanylyl cyclase 2 shortName evidence="14"RETGC-2 ecNumber evidence="13"4.6.1.2 alternativeName: fullName evidence="15"Guanylate cyclase 2F, retinal alternativeName: Guanylate cyclase F shortName: GC-F alternativeName: Rod outer segment membrane guanylate cyclase 2 shortName: ROS-GC2 |
| geneName | GUCY2F GUC2F RETGC2 |
| identifier | P51841 |
| isSequenceChanged | FALSE |
| keyword | Cell projection cGMP biosynthesis Disulfide bond GTP-binding Lyase Membrane Nucleotide-binding Proteomics identification Reference proteome Sensory transduction Signal Transmembrane Transmembrane helix Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GUCY2F |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987865] ENSEMBL:ENSG00000101890 GUCY2F [Homo sapiens] |
| secondaryIdentifier | GUC2F_HUMAN Q9UJF1 |
| sequenceLength | 1108 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:74919] GUCY2F [photoreceptor disc membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P51841 GUCY2F (53278)
