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Details on Person UniProt:P99999 CYCS
| Class:Id | ReferenceGeneProduct:53260 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-105 added on Fri February 6 2015;initiator methionine:1 for 53260 removed on Fri Nov 03 2023;initiator methionine: for 53260 added on Fri Nov 03 2023;initiator methionine: for 53260 removed on Fri Aug 15 2025;initiator methionine:1 for 53260 added on Fri Aug 15 2025 |
| _displayName | UniProt:P99999 CYCS |
| _timestamp | 2025-08-15 22:07:16 |
| chain | initiator methionine:1 chain:2-105 |
| checksum | 8EE9689E0102506B |
| comment | FUNCTION Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.FUNCTION Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.INTERACTION Loosely associated with the inner membrane.PTM Binds 1 heme c group covalently per subunit.PTM Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cytochrome c family.ONLINE INFORMATION Life shuttle - Issue 76 of November 2006ONLINE INFORMATION An unexpected place - Issue 88 of November 2007 |
| description | recommendedName: Cytochrome c |
| geneName | CYCS CYC |
| identifier | P99999 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Apoptosis Direct protein sequencing Disease variant Electron transport Heme Iron Metal-binding Mitochondrion Phosphoprotein Proteomics identification Reference proteome Respiratory chain Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CYCS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2466374] ENSEMBL:ENSG00000172115 CYCS [Homo sapiens] |
| secondaryIdentifier | CYC_HUMAN A4D166 B2R4I1 P00001 Q6NUR2 Q6NX69 Q96BV4 |
| sequenceLength | 105 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:53259] CYCS [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:114244] CYCS [mitochondrial intermembrane space] [Homo sapiens] [EntityWithAccessionedSequence:352607] Cytochrome c (oxidised) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:352608] apo-CYCS [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:352609] Cytochrome c (reduced) [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:5688308] AcK-CYCS [mitochondrial intermembrane space] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5688287] N6-acetyl-L-lysine at unknown position [GroupModifiedResidue:9866219] heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 15 [GroupModifiedResidue:9866223] heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 18 [GroupModifiedResidue:9866226] heme-bis-L-cysteine (ferriheme c di-L-cysteine(1-) residue) at 15 [GroupModifiedResidue:9866235] heme-bis-L-cysteine (ferriheme c di-L-cysteine(1-) residue) at 18 |
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No pathways have been reviewed or authored by UniProt:P99999 CYCS (53260)
