Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O60266 ADCY3
| Class:Id | ReferenceGeneProduct:53236 |
|---|---|
| _chainChangeLog | chain:1-1144 added on Fri February 6 2015 |
| _displayName | UniProt:O60266 ADCY3 |
| _timestamp | 2025-02-21 20:06:09 |
| chain | chain:1-1144 |
| checksum | B75D39DD0A8ACA12 |
| comment | FUNCTION Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.CATALYTIC ACTIVITY ATP = 3',5'-cyclic AMP + diphosphateCOFACTOR Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).ACTIVITY REGULATION Specifically activated by the G alpha protein GNAL/G(olf) in signaling cascades triggered by odorant receptors. Activated by forskolin. After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity.SUBCELLULAR LOCATION Also detected in the cytoplasm, close to lipid droplets.ALTERNATIVE PRODUCTS Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).DOMAIN The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.PTM Sumoylated. Sumoylation is required for targeting ot olfactory cilia.PTM N-glycosylated.PTM Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.POLYMORPHISM Genetic variations at the ADCY3 locus define the body mass index quantitative trait locus 19 (BMIQ19) [MIM:617885]. Variance in body mass index is a susceptibility factor for obesity.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| description | recommendedName: Adenylate cyclase type 3 ecNumber evidence="4"4.6.1.1 alternativeName: ATP pyrophosphate-lyase 3 alternativeName: Adenylate cyclase type III shortName: AC-III alternativeName: Adenylate cyclase, olfactive type alternativeName: fullName evidence="16"Adenylyl cyclase 3 shortName evidence="15"AC3 |
| geneName | ADCY3 KIAA0511 |
| identifier | O60266 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Calmodulin-binding cAMP biosynthesis Cell membrane Cell projection Cytoplasm Glycoprotein Golgi apparatus Isopeptide bond Lyase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Obesity Olfaction Phosphoprotein Proteomics identification Reference proteome Repeat Sensory transduction Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ADCY3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993439] ENSEMBL:ENSG00000138031 ADCY3 [Homo sapiens] |
| secondaryIdentifier | ADCY3_HUMAN B3KT86 Q53T54 Q9UDB1 |
| sequenceLength | 1144 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966417] UniProt:O60266-1 ADCY3 [Homo sapiens] [ReferenceIsoform:8966418] UniProt:O60266-2 ADCY3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:379051] ADCY3 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60266 ADCY3 (53236)
