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Details on Person Canonical WNT signaling through the atypical receptor RYK

Class:Id	Reaction:5323545
_displayName	Canonical WNT signaling through the atypical receptor RYK
_doRelease	TRUE
_timestamp	2016-10-05 16:20:45
authored	[InstanceEdit:5263025] Rothfels, K, 2014-02-10
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:5323544] Rothfels, K, 2014-02-15
edited	[InstanceEdit:5323556] Rothfels, K, 2014-02-15
input	[EntityWithAccessionedSequence:3006746] RYK [plasma membrane] [Homo sapiens] [DefinedSet:5323535] RYK-binding WNTs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4549494] Ryks: new partners for Wnts in the developing and regenerating nervous system [LiteratureReference:4549492] Ryk: a novel Wnt receptor regulating axon pathfinding [LiteratureReference:4549498] The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum [LiteratureReference:4549489] Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth [LiteratureReference:4549491] Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract [LiteratureReference:4549501] The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling [LiteratureReference:5099842] Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping [LiteratureReference:5323443] Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/?-catenin signaling [LiteratureReference:5323417] Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis
modified	[InstanceEdit:5334723] Matthews, Lisa, 2014-02-25 [InstanceEdit:6782917] Rothfels, Karen, 2015-06-09 [InstanceEdit:8941666] Rothfels, Karen, 2016-10-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Canonical WNT signaling through the atypical receptor RYK
output	[Complex:5323537] RYK:WNTs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3247843] secretion of WNT ligands [Homo sapiens] [BlackBoxEvent:3247844] WNT ligands traffic to the plasma membrane [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644752] R-HSA-5323545.4
summation	[Summation:5323533] RYK is an atypical receptor tyrosine kinase-like receptor th...
(hasEvent)	[Pathway:201681] TCF dependent signaling in response to WNT [Homo sapiens]
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No pathways have been reviewed or authored by Canonical WNT signaling through the atypical receptor RYK (5323545)