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Details on Person FRAT proteins bind GSK3beta

Class:Id	Reaction:5323526
_displayName	FRAT proteins bind GSK3beta
_doRelease	TRUE
_timestamp	2014-11-20 02:41:18
authored	[InstanceEdit:5263025] Rothfels, K, 2014-02-10
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5323529] Rothfels, K, 2014-02-15
edited	[InstanceEdit:5323556] Rothfels, K, 2014-02-15
input	[DefinedSet:1226058] FRAT1,2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2997551] GSK3B [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5323409] Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas [LiteratureReference:5323452] Re-evaluating the role of Frat in Wnt-signal transduction [LiteratureReference:5323429] GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis [LiteratureReference:5323415] Characterization and functional analysis of the murine Frat2 gene [LiteratureReference:5323404] A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin [LiteratureReference:5323437] Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification [LiteratureReference:5323433] Identification of the Axin and Frat binding region of glycogen synthase kinase-3 [LiteratureReference:5323430] Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin [LiteratureReference:5323460] The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation [LiteratureReference:196219] Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex [LiteratureReference:5323410] Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 [LiteratureReference:5323423] Frat is dispensable for canonical Wnt signaling in mammals [LiteratureReference:5323425] Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways [LiteratureReference:5323426] Frat2 mediates the oncogenic activation of Rac by MLL fusions
modified	[InstanceEdit:5334723] Matthews, Lisa, 2014-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FRAT proteins bind GSK3beta
output	[Complex:1226052] FRAT1,2:GSK3beta [cytosol] [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644584] R-HSA-5323526.2
summation	[Summation:5323528] The FRAT genes, which were initially identified as a target ...
(hasEvent)	[Pathway:4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane [Homo sapiens]
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