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Details on Person UniProt:Q08828 ADCY1
| Class:Id | ReferenceGeneProduct:53232 |
|---|---|
| _chainChangeLog | chain:1-1119 added on Fri February 6 2015 |
| _displayName | UniProt:Q08828 ADCY1 |
| _timestamp | 2024-11-03 19:55:01 |
| chain | chain:1-1119 |
| checksum | E8DDC8FCB58743D7 |
| comment | FUNCTION Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).CATALYTIC ACTIVITY ATP = 3',5'-cyclic AMP + diphosphateCOFACTOR Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).ACTIVITY REGULATION Activated by G(s) G alpha protein GNAS. Inhibited by G(i) G alpha protein GNAI1. Is further activated by the complex formed by GNB1 and GNG2. Activated by calcium/calmodulin. Inhibited by the ATP analogs adenosine, 2'-deoxyadenosine and 2'-deoxy-3'-AMP.SUBUNIT Interacts with CALM.SUBCELLULAR LOCATION Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.TISSUE SPECIFICITY Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.DOMAIN The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.PTM N-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| description | recommendedName: Adenylate cyclase type 1 ecNumber evidence="3"4.6.1.1 alternativeName: ATP pyrophosphate-lyase 1 alternativeName: Adenylate cyclase type I alternativeName: Adenylyl cyclase 1 alternativeName: Ca(2+)/calmodulin-activated adenylyl cyclase |
| geneName | ADCY1 |
| identifier | Q08828 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Biological rhythms Calmodulin-binding cAMP biosynthesis Cell membrane Cytoplasm Deafness Glycoprotein Lyase Magnesium Manganese Membrane Metal-binding Non-syndromic deafness Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ADCY1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991701] ENSEMBL:ENSG00000164742 ADCY1 [Homo sapiens] |
| secondaryIdentifier | ADCY1_HUMAN A4D2L8 Q75MI1 |
| sequenceLength | 1119 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:53231] ADCY1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q08828 ADCY1 (53232)
